Endocrine Abstracts

Augurin is a putative neuropeptide product of the esophageal cancer-related gene-4. We have previously demonstrated intra-cerebroventricular (ICV) and intra-paraventricular nucleus (iPVN) administration of augurin (71–148) stimulates the hypothalamo-pituitary-adrenal axis in male Wistar rats. This effect was dependent on the release of CRH. Since CRH is known to inhibit feeding, we hypothesised augurin (71–148) would have similar actions. We therefore investigated th...

Nesfatin is an 82 amino acid peptide identified as a novel hypothalamic regulator of feeding. In rodents, central administration of nesfatin acutely inhibits feeding and chronic administration reduces weight gain. Subsequent research has demonstrated nesfatin is involved in the control of puberty in female rats. During puberty i.c.v. administration of nesfatin stimulates release of LH and FSH but has no effect in adult female rats.We investigated the eff...